Personal Information
Sun Zhihua, male, Ph.D, awarded from Fudan University, Professor, School of Chemistry and Chemical Engineering, Shanghai University of Engineering Science. +86-21-67791432, zhihuasun@sues.edu.cn.
Research Fields
1. Organic Synthesis
a) Total synthesis of Bioactive Natural Products
b) Total synthesis of complex compounds which are based on drug design.
c) Methodology of a transition metal-catalyzed coupling .
d) Methodology of construction of the amino boric acid and non-natural amino acids.
e) Methodology of building a variety of heterocyclic.
f) Methodology Construction of the fluorine-containing compound.
2. Medicinal Chemistry and Design
a) Design of the active compound which is based on protein crystal structure.
b) The scope of the study is mainly in the tumor, anti-viral ( hepatitis B, hepatitis C, AIDS),type 2 diabetes.
c) Drug design which is based on the role of small molecular fragments library and the target number of points.
Research Achievements
1. Kun Wen, Han Wang, Jinbo Chen, He Zhang, Xiaodan Cui, Chao Wei, Erkang Fan, Zhihua Sun*, Improving Carbene-Copper Catalyzed Asymmetric Synthesis of alpha-Aminoboronic Esters Using Benzimidazole-Based Precursors; The Journal of Organic Chemistry, 2013, 78, 3405-3409.
2. Kun Wen, Jinbo Chen, Feng Gao, Pinaki S. Bhadury, Erkang Fan and Zhihua Sun*, Metal free catalytic hydroboration of multiple bonds in methanol using N-heterocyclic carbene under open atmosphere; Organic & Biomolecular Chemistry, 2013, 11, 6350-6356.
3. Ya Li*, Tao Zheng, Wei Wang, Yingchao Ma, Wei Xu, Han Wang and Zhihua Sun*; Highly Stereoselective and Practical Synthesis of α-Trichloromethyl Amines and 2,2-Dichloroaziridines from Chloroform; Advanced Synthesis & Catalysis; 2012, 354(2-3), 308-312.
4. Zhihua Sun*, Han Wang, Kun Wen, Ya Li and Erkang Fan; Solvent free or low solvent large scale preparation of chloropyrimidine and analogs; The Journal of Organic Chemistry; 2011, 76, 4149-4153.
5. Hua Zhang, Ya Li, Wenrui Zheng, Pei Zhou and Zhihua Sun*；Practical and Stereoselective Synthesis of β-Amino Sulfones from Alkyl Phenyl Sulfones and N-(tert-Butylsulfinyl) Aldimines; Organic & Biomolecular Chemistry, 2011, 9(19), 6502-6505.
